KMID : 0357920000340110953
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Korean Journal of Pathology 2000 Volume.34 No. 11 p.953 ~ p.956
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Epithelioid Angiomyolipoma of the Kidney - A case report -
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Kim Yu-Kyung
Lee Jong-Sil Chung Ky-Hyun Park Sun-Hoo Ko Gyung-Hyuck
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Abstract
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Angiomyolipoma is considered by many authors to be a hamartoma, occurring in a sporadic form or in association with tuberous sclerosis. This lesion consists of thick walled blood vessels, smooth muscle, and mature adipose tissue in varying amounts. We have experienced a case of the angiomyolipoma composed of monotypic epithelioid cells. The patient was a 69-year-old female. Clinically, there was no evidence of tuberous sclerosis. Microscopically, the tumor was composed of polygonal cells with abundant eosinophilic granular or clear cytoplasm, pleomorphic nuclei, prominent nucleoli, and multinucleated giant cells. The tumor cells showed positive reaction for HMB45, CD68, smooth muscle actin, and S-100, and negative reaction for epithelial membrane antigen, cytokeratin, vimentin, desmin, CD34, estrogen receptor, and progesterone receptor. Ultrastructual analysis showed the presence of glycogen, mitochondria, and other microorganelles in neoplastic cells. Melanosome or premelanosome was not identified.
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KEYWORD
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Epithelioid angiomyolipoma, Kidney
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